Professors

Professor Xianting Ding



Dr. Xianting Ding is professor at School of Biomedical Engineering, deputy director of Institute for Personalized Medicine, Shanghai Jiao Tong University. He is elected into the Chinese Top Elite Researcher Program, Qiushi Foundation Elite Young Investigator, Southern California Scientist and Engineering Association Elite Young Researcher. He received his Ph.D. degree from Department of Mechanical Engineering at University of California, Los Angeles (UCLA). His research interests focus on single cell protein analysis with trace clinical specimens. The technique developed in his lab includes: 1) mass cytometry (also named, CyTOF) technique for single-cell analysis; 2) tissue topology mass spectrometry (in situ single-cell multiplex protein analysis on tissue specimens); 3) portable bio-sensors with microfluidics, bio-electrochemistry, hydrogel and surface modification skills for point-of care technologies(POCT). He participated in the early investigation and development for 3 multi-million-USD international research centers. He is on the editorial board member for Scientific Reports and SLAS Technology (JALA), the reviewer for 20 SCI journals, published 90 peer reviewed SCI papers and filed 30 national or international patents.

Email: dingxianting@sjtu.edu.cn
Phone: +86-21-62932274

Research interests:

  1. Single-cell mass cytometry (also named, CyTOF) technique for single-cell multiplexed protein analysis. We are developing CyTOF platform that allows accurate measuring of various molecular species on single cells in a highly multiplexed fashion.
  2. Tissue in situ high through mass spectrum imaging that enables cellular and molecularly specific omics for multiplexed protein and RNA analysis without the need to digest the tissue into suspended single cells.
  3. Single-cell Western blot technique that allows quantification of 7~10 protein expressions on a single cell using Western blot setup.
  4. Portable bio-sensors for disease diagnosis with microfluidics, bio-electrochemistry, hydrogel and surface modification skills for point-of care technologies (POCT). The applications include circulating tumor cell (CTC) separation, portable PCR platform, single-exosome analysis, etc.

Selected publications:

  1. Xianting Ding*, Zach Njus, Taejoon Kong, Wenqiong Su, Chih-Ming Ho and Santosh Pandey*, Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique, Science Advances, 2017, 3(10): eaao1254.
  2. Antony Warden#, Wenjia Liu, Huixing Chen, Xianting Ding*, Portable Infrared Isothermal PCR platform for multiple STD strand detection, Analytical Chemistry, 2018, 90(20): 11760-11763.
  3. Aynur Abdulla#, Wenjia Liu, Azarmidokht Gholamipour-Shirazi, Jiahui Sun, Xianting Ding*, High-throughput Isolation of Circulating Tumor Cells Using Cascaded Inertial Focusing Microfluidic Channel, Analytical Chemistry, 2018, 90(7): 4397-4405.
  4. Shuopeng Liu#, Wenqiong Su, Yulong Li, Lulu Zhang and Xianting Ding*, Manufacturing of an electrochemical biosensing platform based on hybrid DNA hydrogel: Taking lung cancer-specific miR-21 as an example, Biosensors and Bioelectronics, 2018, 103: 1-5.
  5. Yuting Yang#, Guangxia Shen, Hui Wang, Hongxia Li, Ting Zhang, Nongjian Tao, Xianting Ding*, Hui Yu*, Interferometric Plasmonic Imaging and Detection of Single Exosomes, Proceedings of the National Academy of Sciences (PNAS), 2018, 115 (41) 10275-10280.


Researchgate: https://www.researchgate.net/profile/Xianting_Ding


中国中组部“青年千人”计划获得者;求是基金会“求是杰出青年奖”获得者;世界经济论坛新领军者年会(夏季达沃斯论坛)“青年科学家”;美国南加州中华科学家工程师协会“青年科学家”奖获得者;上海市科协“飞翔计划”获得者。


担任美国比尔.盖茨基金会(Bill & Melinda Gates Foundation)“肺结核和艾滋病组合药物的临床研发”专项,中国负责人;中国科技部十二五“重大新药创制专项”,项目负责人;军委科技委国防创新特区第一批启动项目,课题负责人;中国科技部“国家重点研发计划”前沿和共性技术创新,课题负责人;中国卫计委“艾滋病和病毒性肝炎等重大传染病防治”重大科技专项,任务负责人;上海市科技创新行动计划负责人;国家自然基金项目负责人等。曾经或正在负责20余项国际合作项目(合作研究所包括美国、日本、瑞士、意大利、台湾、香港等)。


2012年3月获得美国加州大学洛杉矶分校(UCLA)博士学位,2013年1月进入上海交通大学任特别研究员,与美国工程院院士、美国科学促进会(AAAS)院士、台湾中央研究院院士、中组部“顶尖千人计划”获得者、美国UCLA前科研副校长何志明(Chih-Ming Ho)院士共同创建上海交通大学个性化医学研究院,并担任研究院常务副院长。


参与过3个国际大型科研中心的建立:美国国家航空航天局(NASA)资助成立的Institute for Cell Mimetic Space Exploration (CMISE);美国国立卫生研究院(NIH)资助成立的Center for Cell Control(CCC);中国教育部和财政部资助成立的上海交通大学Institute for Personalized Medicine (IPM)。


目前担任20个国际SCI期刊审稿人,2个国际SCI期刊的编委会成员,已发表包括Science Advances, Biosensors & Bioelectronics, Biofabrication, Nature Communications, PNAS, Nature Protocols, Analytical Chemistry在内的国际期刊论文70余篇,申请国内外发明专利30余项。


目前担任上海市免疫学会免疫遗传专业委员会,常务委员;上海市药学会药物治疗专业委员会,委员;上海医学会神经免疫学会,委员;中央军委科技委国防科技创新特区变革性交叉科学技术领域专家组,专家委员;全国卫生产业协会实验医学专家委员会青年委员会,委员; 中国妇幼保健协会青年工作委员会,副主委;国际人类表型组计划专家组,专家委员;全国发酵工程技术工作委员会智能制造专业委员会,委员;民盟中央青年工作委员会,委员等社会学术团体职务。


科研方向主要面向国防安全和社会应用开发痕量样本的精准体外诊断技术 :1. 痕量临床样本检验新原理和新技术;2. 痕量临床样本检验装置的集成化和微型化;3. 基于痕量临床样本的药物敏感性检测技术。已开发的平台技术包括:1) 个体化精准诊断技术,通过生物工程手段,如微纳米流体(Microfluidics)、单细胞质谱流式技术(CyTOF)、生物电化学技术(bio-electrochemical)等,对癌症、传染病、代谢病等重大疾病开展多靶标的个体化早期诊断;2) 个体化精准治疗技术,通过工程反馈系统控制技术(Feedback System Control)、切片拓扑学(Tissue Topology)、单细胞蛋白印迹(Single Cell Westernblot)、计算生物学(Computational Biology)等手段,研究多药物组合(包括中药和西药)与生物复杂系统间相互作用。


研究方向:单细胞组学,单细胞蛋白检测技术、单细胞多组学共检测技术、体外诊断,生物传感器,微流芯片技术


 

Professor Xianting Ding

 

Single Cell Handing; CyTOF; Mass Spectrum Imaging; Microfluidics; Personalized/Precision Medicine

Deputy Director, Institute for Personalized Medicine; Professor, School of Biomedical Engineering; Editorial Board Member, Scientific Reports and SLAS Technology(JALA)

Professor Chih-Ming Ho

 

Bio-nano Technology; Micro/Nano Fluidics; Turbulence; Bio-Complex System Control

Distinguished Professor, School of Engineering, UCLA; Director, Institute for Personalized Medicine; Member, National Academy of Engineering; Member, Academia Sinica; Fellow, American Institute of Aeronautics and Astronautics; Fellow, American Physical Society

Quick Contact

For procedural questions regarding human resources, international affairs, or directions to the lab, please contact:
Tel: +86-021-62932274
Fax: +86-021-62932302
Email: dingxianting@sjtu.edu.cn