Recent Research Publications:


1. Jiahui Sun, Wenjia Liu, Yulong Li, Azarmidokht Gholamipour-Shirazi, Aynur Abdulla, Xianting Ding, An on-chip cell culturing and combinatorial drug screening system, Microfluidics and Nanofluidics, (2017) 21:125

2.(Featured articles) Wenjia Liu#, Mingfang Zhang, Xiaoyan Liu, Alok Sharma, Xianting Ding*, “A Point-of-Need infrared mediated PCR platform with compatible lateral flow strip for HPV detection”, Biosensors and Bioelectronics, DOI: 10.1016/j.bios.2017.04.047

3. (Featured articles) Wenjia Liu#, Yiyang Li, Xianting Ding*, Cell adhesion pattern created by OSTE polymers, Biofabrication, 9(2):025006, 2017

4. Xiaolu Zhu# and Xianting Ding*, “Study on a 3D Hydrogel-Based Culture Model for Characterizing Growth of Fibroblasts under Viral Infection and Drug Treatment”, SLAS Discovery, 1-9,, accepted, 2017.

5. Xiaolong Jia#, Yiyang Li#, Alok Sharma, Yulong Li, Guohai Xie, Guoyao Wang, Junhui Jiang, Yue Cheng, Xianting Ding*, “Application of sequential two-level factorial design and three-level orthogonal array composite design (OACD) to study combination of 5 prostate cancer drugs”, Computational biology and chemistry, 67:234-243, 2017

6. Boqian Wang#, Xianting Ding*, and Fei-Yue Wang*, “Determination of Polynomial Degree in the Regression of Drug Combinations”, IEEE/CAA Journal of Automatica Sinica, 4(1): 41-47, 2017

7. Ieong Wong#, Wenjia Liu#, Chih-Ming Ho* and Xianting Ding*, “Continuous Adaptive Population Reduction (CAPR) for Differential Evolution Optimization”, SLAS Technology, 1:17,2017

8. (Featured articles) Bai-Yu Lee#, Daniel Clemens#, Aleidy Silva, Barbara Dillon, Saša Masleša-Galić, Susana Nava, Xianting Ding, Chih-Ming Ho*, and Marcus Horwitz*, "Drug Regimens Identified and Optimized by Output-Driven Platform Markedly Reduce Tuberculosis Treatment Time" , Nature Communications, 8:14183, 2017

9. Jinjin Lin#, Hui Jiang, Xianting Ding*, “Synergistic combinations of five single drugs from Centella asiatica for neuronal differentiation”, Neuroreport, 2017 Jan 1;28(1):23-27


1. Wenqiong Su#, Jiamei Xu, Xianting Ding*,” An electrochemical pH sensor based on the amino-functionalized graphene and polyaniline composite film”, IEEE Trans Nanobioscience, 2016, 15(8):812-819.

2. Shuopeng Liu#, Wenqiong Su, Xianting Ding*, “A Review on Microfluidic Paper-based Analytical Devices (μPADs) for Glucose Detection”, Sensors, 2016, 16(12), pii: E2086

3. Yue, Ji, Liu, Zhen, Cai, Xingyu, Ding, Xianting, *Chen, Shouhui, *Tao, Ke, *Zhao, Tingbao, “Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection”, Talanta, 2016, 150, pp 503-509

4. HuiJiang#, Guoshuai Zheng, Junwei Lv, Heyu Chen, Jinjin Lin, Yiyang Li, Guorong Fan*, XiantingDing*, “Identification of Centella asiatica's effective ingredients for inducingthe neuronal differentiation”, Evidence-Based Complementary and Alternative Medicine, 2016, 2016:9634750

5. Xianting Ding#*, “Drug screening: Drug repositioning needs a rethink”. Nature. 2016, 535(7612):355 (correspondence)

6. (Featured articles) Ali Zarrinpar#, Dong-Keun Lee#, Aleidy Silva#, Nakul Datta, Theodore Kee, Calvin Eriksen, Keri Weigle, Vatche Agopian, Fady Kaldas, Douglas Farmer, Sean E. Wang, Ronald Busuttil, Chih-Ming Ho*, Dean Ho*, “Individualizing liver transplant immunosuppression using a phenotypic personalized medicine platform”, Science Translational Medicine, 2016, 8(333): 333ra49

7. Yiwei Wang#, Jiayi Yu, Ran Cui, Jinjin Lin, and Xianting Ding*, “Curcumin in Treating Breast Cancer: A Review”, Journal of Laboratory Automation, 2016, Epub, DOI: 10.1177/2211068216655524

8. Dan Li#, Wei Deng*, Hu Xu, Yinxing Sun, Yuhong Wang, Shouhui Chen*, and Xianting Ding, “Electrochemical Investigation of Coenzyme Q10 on Silver Electrode in Ethanol Aqueous Solution and Its Determination Using Differential Pulse Voltammetry”, Journal of Laboratory Automation, 2016, Epub, DOI: 10.1177/2211068216644442

9. Xianting Ding#, Bing Zhang, Jian Yang*, Zhijun Ma and Gang Fan, “Use of feedback system control in optimizing chemical combinations to synthesize nanoparticles with desired characteristics”, RSC Advances, 2016, 2016(6): 28322-28330

10. (Featured articles) Aleidy Silva#, Theodore Kee, Xianting Ding, Bai-Yu Lee, Chih-Ming Ho* and Marcus Horwitz*, “Output-Driven Feedback System Control Platform Optimizes Combinatorial Therapy of Tuberculosis using a Macrophage Cell Culture Model”, Proceedings of the National Academy of Sciences (PNAS), 2016, 113(15):E2172-9

11. Hao Li#, Zhengyun Zhang, Zunqiang Zhou, Xianting Ding* and Guangwen Zhou*, “Optimal combination of gemcitabine, sorafenib and S-1 shows increased efficacy in treating cholangiocarcinoma in vitro and in vivo”, anti-cancer drugs, 2016, 27(7):600-608

12. (Featured articles) Patrycja Nowak-Sliwinska#*, Andrea Weiss, Xianting Ding, Paul J Dyson, Hubert van den Bergh, Arjan W Griffioen and Chih-Ming Ho*, “Optimization of drug combinations using Feedback System Control”, Nature Protocols, 2016, 11(2): 302-15


1. (Featured articles) Zhonghao Su#, JinYe#, Zhenxia Qin* and Xianting Ding*, “Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro”, Scientific Reports, 2015, 5: 18314

2. (Featured articles) Andrea Weiss#, Robert H. Berndsen, Xianting Ding*, Chih-Ming Ho, Paul J. Dyson, Hubert van den Bergh, Arjan W. Griffioen and Patrycja Nowak-Sliwinska*, “A streamlined search technology for identification of synergistic drug combinations”, Scientific Reports, 2015, 5: 14508

3. Xianting Ding#*, “New Developments in Biosensing Technologies”, Journal of Laboratory Automation, 2015, 20(4): 311–315

4. (Featured articles) Qi Liu#, Cheng Zhang#, Xianting Ding#, Hui Deng, Daming Zhang, Wei Cui, Hongwei Xu, Yingwei Wang, Wanhai Xu, Lei Lv, Hongyu Zhang, Yinghua He, Qiong Wu, Moshe Szyf, Chih-Ming Ho*, Jingde Zhu*, “Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform”, Scientific Reports, 2015, 5:11464

5. Xianting Ding#*, Kyle Matsuo, Lin Xu, Jian Yang and Longpo Zheng, “Optimized combinations of Bortezomib, Camptothecin and Doxorubicin show increased efficacy and reduced toxicity in treating oral cancer”, Anti-Cancer Drugs, 2015, 26(5): 547-54

6. Andrea Weiss#, Xianting Ding, Judy R. van Beijnum, Ieong Wong, Tse J. Wong, Robert H. Berndsen, Olivier Dormond, Marchien Dallinga, Li Shen, Reinier O. Schlingemann, Roberto Pili, Chih-Ming Ho, Paul J. Dyson, Hubert van den Bergh, Arjan W. Griffioen, Patrycja Nowak-Sliwinska*, “Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer”, Angiogenesis, 2015, 18(3): 233-244

7. (Featured articles) Shuopeng Liu#, Wenqiong Su, Zonglin Li, Xianting Ding*, “Electrochemical detection of lung Cancer specific microRNAs using 3D DNA origami nanostructures”, Biosensors and Bioelectronics, 2015, 15(71): 57-61

8. (Featured articles) Zonglin Li#, Wenqiong Su, Shuopeng Liu, Xianting Ding*, “An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH”, Biosensors and Bioelectronics, 2015, 15(69): 287-293

9. Shouhui Chen#, Qifeng Li#, Yan Xu, Hao Li, and Xianting Ding*, “Gold nanorods Bioconjugates for Intracellular Delivery and Cancer cell Apoptosis”, Journal of Laboratory Automation, 2015, 20(4): 418-422

10. Wengqiong Su#, Xianting Ding*, “Methods of Endotoxin Detection”, Journal of Laboratory Automation, 2015, 20(4): 354-364

11. Dan-dan Liu#, Yu-mei Xu, Xianting Ding, Jian Yang* and Zhi-jun Ma, “Utilizing the Plateau-Rayleigh Instability with Heat-Driven Nano-Biosensing Systems”, Journal of Laboratory Automation, 2015, 20(4):463-70

12. Yingxin Ma#, Hui Nie, Heyu Chen, Jiefu Li, Yunyi Hong, Ban Wang, Caixia Wang, Jie Zhang, Wei Cao, Mingchao Zhang, Yongning Xu, Xianting Ding, Shan Kai Yin, Xinkai Qu and Weihai Ying*, “NAD+/NADH Metabolism and NAD+-Dependent Enzymes in Cell Death and Ischemic Brain Injury: Current Advances and Therapeutic Implications”, Current Medicinal Chemistry, 2015, 22(10):1239-1247


1. Ding X*, Liu N, Matsuo K, Sun M, Zhao X, “Use of Cell Morphology as an Early Bio-indicator for Viral Infection” , IET Nanobiotechnology, Vol. 8, Issue 1, pp. 24-30 (2014)

2. Xu H*, Jaynes J and Ding X, “Combining Two-Level and Three-Level Orthogonal Arrays for Factor Screening and Response Surface Exploration”, Statistica Sinica, Vol. 24 pp. 269-289 (2014)

3. Ma Y, Wu D, Ding X, Ying W*, “CD38 plays key roles in both antioxidation and cell survival of H2O2-treated primary rodent astrocytes”, Int J Physiol Pathophysiol Pharmacol, Vol. 6, Issue 2, pp. 102-108 (2014)

4. Wang B, Ma Y, Kong X, Ding X, Gu H, Chu T, Ying W *, “NAD+ Administration Decreases Doxorubicin-Induced Liver Damage of Mice by Enhancing Antioxidation Capacity and Decreasing DNA Damage”, Chemico-Biological Interactions, Vol. 212, Issue 5, pp. 65–71 (2014)

5. Wang C, Chen H, Zhang J, Hong Y, Ding X, Ying W*. “Malate-aspartate shuttle mediates the intracellular ATP levels, antioxidation capacity and survival of differentiated PC12 cells”. Int J Physiol Pathophysiol Pharmacol. Vol. 12, Issue 6, pp. 109-114 (2014)

6. Hong Y, Nie H, Wu D, Wei X, Ding X, Ying W *, “NAD+ treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells”, Neuroscience Letters, Vol. 560, Issue 7, pp. 46–50 (2014)

7. Wang W, Guo J, Zhang S, Yang J*, Ding X, Zhan X, "Numerical study on hydrodynamic characteristics of plate-fin heat exchanger using porous media approach", Computers & Chemical Engineering Vol. 61, pp. 30-37 (2014)

8. (Featured articles) Ding X*, Liu W, Weiss A, Li Y, Wong I, Griffioen A, van den Bergh H, Xu H, Nowak-Sliwinska P, Ho CM, “Discovery of a low order drug-cell response surface for applications in personalized medicine”, Physical Biology, Vol.,11, Issue 6, Article Number: 065003 (2014)


1. Yu H, Zhang WL, Ding X, Zheng KY, Ho CM, Tsim KW, Lee YK*, “Optimizing Combinations of Flavonoids Deriving from Astragali Radix in Activating the Regulatory Element of Erythropoietin by a Feedback System Control Scheme”, Evidence-Based Complementary and Alternative Medicine, Vol. 2013, Article Number 541436 (2013)

2. (Featured articles) Honda Y, Ding X, Mussano F, Wiberg A, Ho CM*, Nishimura I*, “Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control”, Scientific Reports, Vol. 3 Article Number: 3420 (2013)

3. Wang W, Zhang S, Yang J*, Zheng J, Ding X, Chou M, Tang P, Zhan X, “Effects of Distribution Channel Dimensions on Flow Distribution and Pressure Drop in a Plate-Fin Heat Exchanger”, Chemical Engineering & Technology, Vol. 36, Issue 4, pp. 657–664 (2013)

4. Ding, X., Xu, H., Hopper, C., Yang, J., and Ho, C.M., “Use of fractional factorial designs in antiviral drug studies“, Quality and Reliability Engineering International, Vol. 29, Issue 2, pp. 299-304, 2013.

5. Jaynes, J., Ding X., Xu, H., Wong, W.K., and C.M. Ho, “Application of Fractional Factorial Designs to Study Drug Combinations“, Statistics in Medicine, Vol. 32, Issue 2, pp. 307-318, 2013.

6. Wang, H., Silva, A., and Ho, C.M., “When Medicine Meets Engineering – Paradigm Shifts in Diagnostics and Therapeutics”, Diagnostics, Vol. 3, pp. 126-154, 2013.

7. Lillehoj, P.B., Kaplan, C. W., He, J., Shi, W., and Ho, C .M.,”Rapid, Electrical Impedance Detection of Bacterial Pathogens Using Immobilized Antimicrobial Peptides“, Journal of Laboratory Automation, DOI: 10.1177/2211068213495207, 2013

8. Takeuchi, M., Haulot, G. and Ho, C.M., “System Integration of a Novel Cell Interrogation Platform“, IN: Micro-Nano Mechatronics – New Trends in Material, Measurement, Control, Manufacturing and Their Applications in Biomedical Engineering, ed. Fukuda, T., Niimi, T. and Obinata, G., pub. InTech, pp. 299-314 (2013).


1. Chen T.-H., Zhu X., Pan L., Zeng X., Garfinkel A., Tintut Y., Demer L. L., Zhao X., Ho C.M., “Directing Tissue Morphogenesis via Self-Assembly of Vascular Mesenchymal Cells“, Biomaterials, vol. 33, pp. 2019-2026, 2012.

2. Chen T.-H., Guo C., Zhao X., Wong M. N., Tintut Y., Demer L. L., Ho C.M., Garfinkel A., “Patterns of periodic holes created by increased cell motility“, Interface Focus, vol. 2, pp. 457-64, 2012.

3. Chen T.-H., Hsu J. J., Zhao X., Guo C., Wong M. N., Huang Y., Li Z., Garfinkel A., Ho C.M., Tintut Y., Demer L. L., “Left-Right Symmetry Breaking in Tissue Morphogenesis via Cytoskeletal Mechanics“, Circulation Research, vol. 110, pp. 551–559, 2012.

4. Ding, X.T, Xu, H.Q, Hopper C., Yang J., and Ho C.M., “Use of Fractional Factorial Designs in Antiviral Drug Studies”, Quality and Reliability Engineering International, DOI: 10.1002/qre.1308, 2012.

5. (Featured articles) Ding, X. T., Sanchez, D. J., Shahangian, A., Al-Shyoukh, I., Cheng, G., and Ho, C. M., “Cascade Search for HSV-1 Combinatorial Drugs with High Antiviral Efficacy and Low Toxicity”, International Journal of Nanomedicine, Vol. 7, 2281-2292, 2012.

6. Jaynes, J., Ding, X.T., Xu, H., Wong, W.K., and Ho, C.M., “Application of Fractional Factorial Designs to Study Drug Combinations”, Statistics in Medicine, DOI, 10.1002/sim.5526, 2012.

7. Wong, I, Ding, X., Wu, C. and Ho, C.M., “Accurate and effective live bacteria microarray patterning on thick polycationic polymer layers co-patterned with HMDS”, RSC Advances, 2 (20), 7673 – 7676, DOI: 10.1039/c2ra20938a, 2012

8. Wei F., Cheng, S., Korin, Y., Reed,E.F., Gjertson, D., Ho,C. M., Gritsch, H.A., and Veale, J., “Serum Creatinine Detection by a Conducting-Polymer-Based Electrochemical Sensor To Identify Allograft Dysfunction”, Analytical Chemistry, 2012.

9. Haulot, G., Benahmed, A. J. and Ho, C. M., “Optoelectronic Reconfigurable Microchannels”, Lab Chip, 12 (23), pp. 5086 – 5092, 2012


1. Wong T.-S., Chen T.-H., Shen X., and Ho C.M., “Nanochromatography Driven by the coffee Ring Effect,“ Analytical Chemistry, vol. 83, pp. 1871–1873, 2011.

2. Valamehr, B., Tsutsui, H., Ho, C.M., and Wu, H., “Developing Defined Culture Systems for Human Pluripotent Stem Cells,” Regenerative Medicine, Vol. 6, pp. 623-634, 2011.

3. (Featured articles) Tsutsui, H., Valamehr, B., Hindoyan, A., Qiao, R., Ding, X., Guo, S., Witte, O.N., Liu, X., Ho, C.M., and Wu, H., “An Optimized Small Molecule Inhibitor Cocktail Supports Long-term Maintenance of Human Embryonic Stem Cells,” Nature Communications, 2:167, DOI:10.1038/ncomms1165, 2011.

4. Wu, Chunsheng, Lillehoj, P.B., Sabet, L., Wang, P. and Ho, C.M., “Ultrasonication on a microfluidic chip to lyse single and multiple Pseudo-nitzschia for marine biotoxin analysis“,Biotechnology Journal, 5(2): 150-155, 2011.

5. Al-Shyoukh, I., Yu, F., Feng, J., Yan, K., Dubinett, S., Ho, C. M., Shamma, J.S. and Sun R., “Systematic quantitative characterization of cellular responses induced by multiple signals“, BMC Systems Biology, Vol. 5, pp. 88, 2011.

6. Yu, F., Al-Shyoukh, I., Feng, J., Li, X., Liao, C.W., Ho, C.M., Shamma, J.S., Sun R., “Control of Kaposi’s Sarcoma-Associated Herpesvirus Reactivation Induced by Multiple Signals”, Plos ONE, Vol. 6, Issue 6, pp. 1-13, 2011.

7. Lee, J., Newbern, S., Tai, Y.C., Ho, C.M., and Huang, P.H., “Flight demonstrations of micro-actuator controlled delta wing”, Aircraft Engineering and Aerospace Technology, Vol. 83, Issue 5, pp. 324-331, 2011.

8. Haulot. G. and Ho, C.M.,“Optoelectronic Heating for Fabricating Microfluidic Circuitry”,Advances in OptoElectronics, Volume 2011, Article ID 237026, doi:10.1155/2011/237026, 2011.

9. Wei, F., Bai, B., and Ho, C. M., “Rapidly optimizing an aptamer based BoNT sensor by feedback system control (FSC) scheme”, Biosensors and Bioelectronics, Vol. 30, pp. 174-179, 2011.